研究成果

原著論文  Google Scholar 
  1. Toda Y. Kaga A. Kajiya-Kanegae H. Hattori T. Yamaoka S. Okamoto M. Tsujimoto H. Iwata H. (2021) Genomic prediction modeling of soybean biomass using UAV-based remote sensing and longitudinal model parameters. Plant Genome. 14: e20157
  2. Vaidya AS. Peterson FC. Eckhardt J. Xing Z. Park SY. Dejonghe W. Takeuchi J. Pri-Tal O. Faria J. Elzinga D. Volkman BF. Todoroki Y. Mosquna A. Okamoto M. Cutler SR. (2021) Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo. Proc. Natl. Acad. Sci. USA. 118: e2108281118
  3. Vaidya AS. Helander JDM. Peterson FC. Elzinga D. Dejonghe W. Kaundal A. Park SY. Xing Z. Mega R. Takeuchi J. Khanderahoo B. Bishay S. Volkman BF. Todoroki Y. Okamoto M. Cutler SR. (2019) Dynamic control of plant water use using designed ABA receptor agonists. Science 366: 6464 (aaw8848)  
  4. Mega R. Tsujimoto H. Okamoto M. (2019) Genetic manipulation of abscisic acid receptors enables modulation of water use efficiency. Plant Signaling & Behavior 14: e1642039 
  5. Fujioka H. Samejima H. Mizutani M. Okamoto M. Sugimoto Y. (2019) How does Striga hermonthica Bewitch its hosts? Plant Signaling & Behavior 14: 1605810 
  6. Fujioka H. Samejima H. Suzuki H. Mizutani M. Okamoto M#. Sugimoto Y#. (2019) Aberrant protein phosphatase 2C leads to abscisic acid insensitivity and high transpiration in parasitic Striga. Nature Plants 5: 258-262
  7. Mega R. Abe F. Kim JK. Tsuboi Y. Tanaka K. Kobayashi H. Sakata, Y. Hanada K. Tsujimoto H. Kikuchi J. Cutler S.R. Okamoto M.# (2019) Tuning water use efficiency and drought tolerance using abscisic acid receptors. Nature Plants 5: 153-159 
  8. Nakaminami K. Okamoto M. Higuchi-Takeuchi M. Yoshizumi T. Yamaguchi Y. Fukao Y. Shimizu M. Ohashi C. Tanaka M. Matsui M. Shinozaki K. Seki M. Hanada K. (2018) AtPep3 is a hormone-like peptide that plays a role in the salinity stress tolerance of plants. Proc. Natl. Acad. Sci. USA. 115: 5810-5815
  9. Takeuchi J*. Mimura N*. Okamoto M*. Yajima S. Sue M. Akiyama T. Monda K. Iba K. Ohnishi T. Todoroki Y. (2018) Structure-Based Chemical Design of Abscisic Acid Antagonists That Block PYL-PP2C Receptor Interactions. ACS Chemical Biology 13: 1313-1321
  10. Edet OU. Kim JS. Okamoto M. Hanada K. Takeda T. Kishii M. Gorafi YSA. Tsujimoto H. (2018) Efficient anchoring of alien chromosome segments introgressed into bread wheat by new Leymus racemosus genome-based markers. BMC Genetics 27: 18
  11. Yoneyama K*. Mori N*. Sato T*. Yoda A. Xie X. Okamoto M. Iwanaga M. Ohnishi T. Nishiwaki H. Asami T. Yokota T. Akiyama K. Yoneyama K. Nomura T. (2018) Conversion of carlactone to carlactonoic acid is a conserved function of MAX1 homologs in strigolactone biosynthesis. New Phytologist 218: 1522-1533
  12. Anabuki T. Tsukahara M. Okamoto M. Matsuura H. Takahashi K. (2018) Novel biotin linker with alkyne and amino groups for chemical labelling of a target protein of a bioactive small molecule. Bioorganic & Medicinal Chemistry Letters 15:783-386
  13. Shirai K. Matsuda F. Nakabayashi R. Okamoto M. Tanaka M. Fujimoto A. Shimizu M. Shinozaki K. Seki M. Saito K. Hanada K. (2017) A highly specific genome-wide association study integrated with transcriptome data reveals the contribution of copy number variations to specialized metabolites in Arabidopsis thaliana accessions. Molecular Biology and Evolution 34: 3111-3122 
  14. Sano N. Kim JS. Onda Y. Nomura T. Mochida K. Okamoto M. Seo M. (2017) RNA-Seq using bulked recombinant inbred line populations uncovers the importance of brassinosteroid for seed longevity after priming treatments. Scientific Reports 14: 8095
  15. Takeuchi J*. Okamoto M*, Mega R. Kanno Y. Ohnishi T. Seo M. Todoroki Y.  (2016) Abscinazole-E3M, a practical inhibitor of abscisic acid 8’-hydroxylase for improving drought tolerance. Scientific Reports 14: 37060
  16. Yan D. Easwaran V. Chau V. Okamoto M. Ierullo M. Kimura M. Endo A. Yano R. Pasha A. Gong Y. Bi YM. Provart N. Guttman D. Krapp A. Rothstein SJ. Nambara E. (2016) NIN-like protein 8 is a master regulator of nitrate-promoted seed germination in Arabidopsis. Nature Communications 7:13179
  17. Okamoto M. Matsui M. Tanaka M. Morosawa T. Ishida J. Iida K. Mochizuki Y. Toyoda T. Seki M. (2016) Sm-like protein-mediated RNA metabolism is required for heat stress tolerance in Arabidopsis. Frontiers in Plant Science fpls.2016.01079
  18. Yamashita Y. Ota M. Inoue Y. Hasebe Y. Okamoto M. Inukai T. Masuta C. Sakihama Y. Hasidoko Y. Kojima M. Sakakibara H. Inage Y. Takahashi K. Yoshihara T. Matsuura H. (2016) Chemical Promotion of Endogenous Amount of ABA in Arabidopsis thaliana by a Natural Product, Theobroxide. Plant & Cell Physiology 57: 986–999
  19. Takeuchi J. Ohnishi T. Okamoto M. Todoroki Y. (2015) The selectivity of 6-nor-ABA and 7′-nor-ABA for abscisic acid receptor subtypes. Bioorganic & Medicinal Chemistry Letters 25 3507–3510
  20. Takeuchi J. Ohnishi T. Okamoto M. Todoroki Y. (2015) Conformationally restricted 3′-modified ABA analogs for controlling ABA receptors. Organic & Biomolecular Chemistry 13, 4278-4288
  21. Takeuchi J.* Okamoto M.* Akiyama T. Muto T. Yamaji S. Sue M. Seo M. Kanno Y. Kamo T. Endo A. Nambara E. Hirai N. Ohnishi T. Cutler SR. Todoroki Y. (2014) Designed abscisic acid analogues as antagonists of PYL-PP2C receptor interactions. Nature Chemical Biology 10:477-482
  22. Okamoto M. Higuchi-Takeuchi M. Shimizu M. Shinozaki K. Hanada K. (2014) Substantial expression of novel small open reading frames in Oryza sativa. Plant Signaling & Behavior e27848-1-3
  23. Okamoto M. Peterson FC. Defries A. Park SY. Endo A. Nambara E. Volkman BF. Cutler SR. (2013) Activation of dimeric ABA receptor elicits guard cell closure, ABA-regulated gene expression and drought tolerance. Proc. Natl. Acad. Sci. USA 110: 12132-7
  24. Hanada K.* Higuchi-Takeuchi M.* Okamoto M. Yoshizumi T. Shimizu M. Nakaminami K. Nishi R. Ohashi C. Iida K. Tanaka M. Horii Y. Kawashima M. Matsui K. Toyoda T. Shinozaki K. Seki M. Matsui M. (2013) Small coding genes associated with morphogenesis are hidden in plant genomes. Proc. Natl. Acad. Sci. USA 110: 2395-400
  25. Kawaguchi S. Iida K. Harada E. Hanada K. Matsui A. Okamoto M. Shinozaki K. Seki M. Toyoda T. (2012) Positional correlation analysis improves reconstruction of full-length transcripts and alternative isoforms from noisy array signals or short reads. Bioinformatics 28: 929-937
  26. Endo A.* Tatematsu K.* Hanada K.* Duermeyer L. Okamoto M. Yonekura-Sakakibara K. Saito K. Toyoda T. Kawakami N. Kamiya Y. Seki M. Nambara E. (2012) Tissue-specific transcriptome analysis reveals cell wall metabolism, flavonol biosynthesis, and defense responses are activated in the endosperm of germinating Arabidopsis thaliana seeds.  Plant & Cell Physiology 53: 16-27
  27. Hanada K. Hase T. Toyoda T. Shinozaki K. Okamoto M. (2011) Origin and evolution of genes related to ABA metabolisms and signaling pathways. Journal of Plant Research 124:455-465
  28. Okamoto M. Kushiro T. Jikumaru Y. Abrams SR. Kamiya Y. Seki M. Nambara E. (2011) ABA 9’-hydroxylation is catalyzed by CYP707A in Arabidopsis. Phytochemistry 72:717-722
  29. Okamoto M. & Seki M. (2011) Expression pattern and 5’-terminal structure of antisense transcripts. Plant Signaling & Behavior 6:691-693
  30. Iida K.* Kawaguchi S.* Kobayashi N. Yoshida Y. Ishii M. Harada E. Hanada K. Matsui A. Okamoto M. Ishida J. Tanaka M. Morosawa T. Seki M. Todyoda T. (2011) ARTADE2DB: Improved Statistical Inferences for Arabidopsis Gene Functions and Structure Predictions by Dynamic-Structure-Based Dynamic Expression (DSDE) Analyses. Plant & Cell Physiology 52:254-64
  31. Okamoto M. Tatematsu K. Matsui A. Morosawa T. Ishida J. Tanaka M. Endo TA. Mochizuki Y. Toyoda T. Kamiya Y. Shinozaki K. Nambara E. Seki M. (2010) Genome-wide analysis of endogenous abscisic acid-mediated transcription in dry and imbibed seeds of Arabidopsis using tiling arrays. Plant Journal 62:39-51
  32. Ikegami K. Okamoto M. Seo M. and Koshiba T. (2009) Activation of abscisic acid biosynthesis in the leaves of Arabidopsis thaliana in response to water deficit. Journal of Plant Research 122:235-243
  33. Okamoto M. Tanaka Y. Abrams SR. Kamiya Y. Seki M. Nambara E. (2009) High humidity induces abscisic acid 8’-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis. Plant Physiology 149: 825-834
  34. Matsui A. Ishida J. Morosawa T. Mochizuki Y. Kaminuma E. Endo TA. Okamoto M. Nambara E. Nakajima M. Kawashima M. Kim JM. Satou M. Kobayashi N. Toyoda T. Shinozaki K. and Seki M. (2008) Arabidopsis Transcriptome Analysis under Drought, Cold, High-Salinity and ABA Treatment Conditions using a Tiling Array. Plant & Cell Physiology 49:1135–1149
  35. Endo A. Sawada Y. Takahashi H. Okamoto M. Ikegami K. Koiwai H. Seo M. Toyomasu T. Mitsuhashi W. Shinozaki K. Nakazono M. Kamiya Y. Koshiba T. and Nambara E. (2008) Drought induction of Arabidopsis 9-cis-epoxycatotenoid dioxygenase 3 occurs in vascular parenchyma cells. Plant Physiology 147:1984–1993
  36. Toh S. Imamura A. Watanabe A. Nakabayashi K. Okamoto M. Jikumaru Y. Hanada A. Aso Y. Ishiyama K. Tamura N. Iuchi S. Kobayashi M. Yamaguchi S. Kamiya Y. Nambara E. and Kawakami N. (2008) High temperature-induced abscisic acid biosynthesis and its role in the inhibition of gibberellin action in Arabidopsis seeds. Plant Physiology 146:1368–1385
  37. Melhorn V. Matsumi K. Koiwai H. Ikegami K. Okamoto M. Nambara E. Bittnerb F. and Koshiba T. (2008) Transient expression of AtNCED3 and AAO3 genes in guard cells causes the stomatal closure inVicia faba L. Journal of Plant Research 121:125-131
  38. Saika H. Okamoto M. Miyoshi K. Kushiro T. Shinoda S. Jikumaru Y. Fujimoto M. Arikawa T. Takahashi H. Ando M. Arimura S. Miyao A. Hirochika H. Kamiya Y. Tsutsumi N. Nambara E. Nakazono M. (2007) Ethylene promotes submergence-induced expression of OsABA8ox1, a gene that encodes ABA 8´-hydroxylase in rice. Plant & Cell Physiology 48:287-298
  39. Lin P. Hwang S. Endo A. Okamoto M. Koshiba T. Cheng W. (2007) Ectopic Expression of ABA2/GIN1 in Arabidopsis Promotes Seed Dormancy and Stress Tolerance. Plant Physiology 143:745-758
  40. Saito S. * Okamoto M. * Shinoda S. Kushiro T. Koshiba T. Kamiya Y. Hirai N. Todoroki Y. Sakata K. Nambara E. Mizutani M. (2006) A Plant Growth Retardant Uniconazole Is a Potent Inhibitor of ABA Catabolism in Arabidopsis. Bioscience, Biotechnology, and Biochemistry 70:1731-1739
  41. Okamoto M. Kuwahara A. Seo M. Kushiro T. Asami T. Hirai N. Kamiya Y. Koshiba T. Nambara E. (2006) CYP707A1 and CYP707A2, which encode ABA 8’-hydroxylases, are indispensable for a proper control of seed dormancy and germination in Arabidopsis. Plant Physiology 141:97-107
  42. Seo M. Hanada A. Kuwahara A. Endo A. Okamoto M. Yamauchi Y. North H. Marion-Poll A. Tai-ping S. Koshiba T. Kamiya Y. Yamaguchi S. Nambara E. (2006) Regulation of hormone metabolism in Arabidopsis seeds: phytochrome regulation of abscisic acid metabolism and abscisic acid regulation of gibberellin metabolism. Plant Journal 48:345-366
  43. Umezawa T. Okamoto M. Kushiro T. Nambara E. Oono Y. Seki M. Kobayashi M. Koshiba T. Kamiya Y. Shinozaki K. (2006) CYP707A3, a major ABA 8’-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana. Plant Journal 46:171-182
  44. Lefebvre V. North H. Frey A. Sotta B. Seo M. Okamoto M. Nambara E. Marion-Poll A. (2006) Functional analysis of Arabidopsis NCED6 and NCED9 genes indicates that ABA synthesised in the endosperm is involved in the induction of seed dormancy. Plant Journal 45: 309-319
  45. Nakabayashi K. Okamoto M. Koshiba T. Kamiya Y. Nambara E. (2005) Genome-wide profiling　of stored mRNA in Arabidopsis thaliana seed germination: epigenetic and genetic regulation of transcription in seed. Plant Journal 41: 697-709
  46. Gazzarrini S. Tsuchiya Y. Lumba S. OkamotoM. McCourt P. (2004) The transcription factor FUSCA3 controls developmental timing in Arabidopsis through the hormones gibberellin and abscisic acid. Developmental Cell 7: 373-385
  47. Kushiro T.* Okamoto M.* Nakabayashi K. Yamagishi K. Kitamura S. Asami T. Hirai N. Koshiba T. Kamiya Y. Nambara E. (2004) The Arabidopsis Cytochrome P450 CYP707A Family Encodes ABA 8’-Hydroxylases: Key Enzymes in ABA Catabolism. EMBO Journal 23: 1647-1656.

(*Co-first authors,  #Corresponding author)

総説等
  1. 岡本昌憲 (2021) ｢乾燥ストレス耐性を付与する分子の開発｣ 日本農薬学会誌, 46, 122-128
  2. Takeuchi J. Fukui K. Seo Y. Takaoka Y. Okamoto M. (2021) Ligand–receptor interactions in plant hormone signaling. Plant Journal, 105, 290–306
  3. 妻鹿 良亮、岡本昌憲 (2020)「アブシシン酸受容体の利用による節水性と耐乾性を兼ね備えたコムギの開発」植物の生長調節 Vol55, No.2 126-130
  4. 山内卓樹、藤井壮太、岡本昌憲、田中佑、水多陽子、晝間敬、吉田健太郎、山本英司、大西孝幸、犬飼義明 (2020)「フィールドにおける生命現象の解明とその制御に向けた基盤技術の創出」育種学研究 22: 75-82
  5. 岡本昌憲、竹内純、轟泰司 (2020) 「アブシシン酸アゴニストの理論設計」植物の生長調節 Vol55, No.1 40-45
  6. 岡本昌憲、 藤岡聖、 杉本幸裕 (2020) 「寄生植物ストライガの養水分奪取機構の解明」化学と生物 Vol58, No.3: 138-140
  7. Dejonghe W*. Okamoto M*. Cutler SR. Small molecule probes of ABA biosynthesis and signaling. (2018) Plant Cell Physiology  Vol.59: 1490-1499
  8. Okamoto M. Cutler SR. (2018) Chemical control of ABA receptors to enable plant protection against water stress  Plant Chemical Genomics p127-141
  9. 岡本昌憲 (2017) ｢アブシジン酸受容体と受容体に作用する化合物について｣ 植調 Vol.50, No.12: 366-371 
  10. 岡本昌憲 (2016) ｢アブシジン酸の代謝と受容に関する化学遺伝学的研究｣ 植物の生長調節 51 (1): 16-23
  11. 岡本昌憲、妻鹿良亮 (2015) ｢植物の乾燥ストレス応答を制御するアブシジン酸の働きとその応用｣ 極限環境生物学会誌 12: 78-88  
  12. Yan D. Tatematsu K. Nakabayashi K. Endo A. Okamoto M. Nambara E. (2015) A comparison of transcriptomes between germinating seeds and growing axillary buds of Arabidopsis, Advances in Plant Dormancy 「Springer」p223-234
  13. Endo A, Okamoto M, Koshiba T. (2014) ABA biosynthetic and catabolic pathways. Abscisic acid: Metabolism, Transport and Signaling, 「Springer Science」21-45.
  14. 竹内純、岡本昌憲、轟泰司 (2014) アブシジン酸受容体のアンタゴニストの合理的な創出 ｢ライフサイエンス新着レビュー｣
  15. Matsui A, Ishida J, Morosawa T, Okamoto M, Kim JM, Kurihara Y, Kawashima M, Tanaka M, To TK, Nakaminami K, Kaminuma E, Endo TA, Mochizuki Y, Kawaguchi S, Kobayashi N, Shinozaki K, Toyoda T, Seki M. (2010) Arabidopsis tiling array analysis to identify the stress-responsive genes. Method in Molecular Biology 「The Humana Press Inc.」 639:141-55.
  16. Nambara E. Okamoto M. Tatematsu K. Yano R. Seo M. Kamiya Y. (2010) Abscisic acid and the control of seed dormancy and germination. Seed Science Research 20:55-67
  17. Seki M. Okamoto M. Matsui A. Kim MJ. Kurihara Y. Kim-To T. and Shinozaki K. (2009) “Microarray analysis for studying plant abiotic stress responses”, Molecular Techniques in Crop Improvement, 2nd edition p333-35
  18. Okamoto M. Hanada A. Kamiya Y. Yamaguchi S. Nambara E. (2009)「Chapter 9 Measurements of abscisic acid and gibberellins by gas chromatography/massspectrometry」Method in Molecular Biology 495: p53-60
  19. 久城哲夫、岡本昌憲 (2009)「ABA 8′位水酸化酵素による種子の発芽調節」種子発芽の生態学、生理学、分子生物学 (種生物学会刊行本)  279-286
  20. 南原英司、岡本昌憲、久城哲夫 (2004) ABA不活性化酵素CYP707A遺伝子の同定と機能解析 ブレインテクノニュース 104:26-29.
  21. 南原英司、岡本昌憲 (2004)「新版　植物ホルモンのシグナル伝達」第４章アブシジン酸；3.アブシジン酸とジベレリンのクロストーク 「植物細胞 工学シリーズ20号レビュー集」（秀潤社）　125-132.
特許およびその他
  1. 米国特許登録 : Sean Cutler、岡本昌憲 (2016) ｢Synthetic Compounds for Vegetative ABA Responses｣ US9345245
  2. 国内特許出願 : 花田耕介、樋口美栄子、吉積毅、中南健太郎、岡本昌憲、関原明、 松井南 (2012) ｢植物の形態形成および／または環境ストレス耐性に関与するポリペプチド｣
  3. 国内特許出願 : 南原英司、神谷勇治、久城哲夫、岡本昌憲 (2003) 「アブシジン酸不活性化に関与する遺伝子」